Biodemographic Models of Reproductive Aging (BIMORA) Project, 1998-2002 [United States] (ICPSR 4452)

Version Date: Oct 25, 2006 View help for published

Principal Investigator(s): View help for Principal Investigator(s)
Maxine Weinstein, Georgetown University; James W. Wood, Pennsylvania State University

Version V2

In the early 1990s, researchers at Georgetown University, Pennsylvania State University, and the University of Utah proposed a five-year longitudinal study of female reproductive aging that would include the collection of hormonal, menstrual cycle, and health data from a group of women in order to advance the current understanding of the transition through menopause. The women selected for the BIMORA project were a subset of women belonging to the Tremin Research Program on Women's Health (TREMIN), a longitudinal, prospective study of menstrual cycles and female reproductive health that was begun in the 1930s by Dr. Alan Treloar at the University of Minnesota. As part of the TREMIN study, women recorded their menstrual cycles on calendar cards and were also asked to fill out annual and later biannual health surveys. The first cohort of women was recruited in the 1930s when many of them were attending the University of Minnesota. Some of their daughters, along with additional women, were recruited in the 1960s as part of a second cohort. Recruitment continued after the second cohort, and a total of 156 TREMIN women participated in the five-year BIMORA project. At the beginning of the study, they ranged in age from 25 to 58 years of age and many were from the second TREMIN cohort. Women could not be using exogenous hormones and had to have at least one intact ovary. The participating women had TREMIN data going back as far as the early 1960s, and they continued sending menstrual bleeding and health data to TREMIN during the BIMORA project. In addition, from January 15 to July 14 in each of the five years of the BIMORA project, participants collected daily urine specimens and made a daily record of medication use, health conditions, and menstrual bleeding. These data were analyzed in the BIMORA laboratory. The urine specimens were assayed for urinary conjugates of estrogen, progesterone, LH, and FSH. The TREMIN data and laboratory data were then merged into a single dataset.

Weinstein, Maxine, and Wood, James W. Biodemographic Models of Reproductive Aging (BIMORA) Project, 1998-2002 [United States]. Inter-university Consortium for Political and Social Research [distributor], 2006-10-25.

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United States Department of Health and Human Services. National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development (1R01HD034159), United States Department of Health and Human Services. National Institutes of Health. National Institute on Aging (1R01AG015141)

This data collection may not be used for any purpose other than statistical reporting and analysis. Use of these data to learn the identity of any person or establishment is prohibited. To protect respondent privacy, some data files in this collection are restricted from general dissemination. To obtain these restricted files, researchers must agree to the terms and conditions of a Restricted Data Use Agreement.

Inter-university Consortium for Political and Social Research
1998 -- 2002
  1. These data are distributed exactly as they arrived from the data depositor. ICPSR has not checked or processed this material. Users should contact the Data Sharing for Demographic Research (DSDR) archive at ICPSR,, if further information is desired.

  2. The data are also made available in a format developed by the investigators to create an SQL database.


A subset of women participating in the TREMIN research who were not using oral contraception nor hormone replacement therapy who had at least one intact ovary.

Women of reproductive age from onset of menstruation to menopause.


TREMIN health questionnaires

BIMORA laboratory data

TREMIN calendar card data



2018-02-15 The citation of this study may have changed due to the new version control system that has been implemented. The previous citation was:
  • Weinstein, Maxine, and James W. Wood. Biodemographic Models of Reproductive Aging (BIMORA) Project, 1998-2002 [United States]. ICPSR04452-v2. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2006-10-25.

2006-10-25 A copy of the restricted data was provided for transfer to the secure server. The CASE.COUNT, VARIABLE.COUNT and LRECL fields were updated with ASCII data information.

2006-07-20 The BIMORA Restricted Data Use Agreement is now available for download.



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