Search results

Showing 1 – 2 of 2 results.

Curated

Comparing Two Ways to Manage Symptoms for Patients Who Have Chronic Migraine and Frequent Medication Use (The MOTS Trial), United States, 2017-2020 (ICPSR 38546)

Released/updated on: 2022-12-14

Geographic coverage: United States

Time period: 2017-02-20--2020-12-22

The Medication Overuse Treatment Strategy (MOTS) research trial sought to understand the relationship between individuals who suffer from chronic migraines and their use (or overuse) of medications to treat their migraines. A diagnosis of chronic migraines means that a person experiences headaches on 15 days or more per month with at least 8 of those days meeting the diagnostic criteria for migraine with or without aura. Of the nearly 7 million individuals in the United States who suffer from chronic migraines more than half of them overuse medication intended to relieve the symptoms. However, that overuse can bring about other medical issues. This research trial enrolled 720 chronic migraine sufferers from 34 clinics across the country. The subjects were randomized into two groups. A total of 361 patients were randomized to the treatment strategy that included migraine-preventive therapy with switching off the overused medication to an alternative used with a limited frequency, while 359 patients were randomized to migraine-preventive medication with continuation of the overused medication with no maximum limit.

Curated

Reduction of Health Disparities in Appalachians with Multiple Cardiovascular Disease Risk Factors: A Randomized Controlled Trial, 2013-2016 (ICPSR 36985)

Released/updated on: 2018-02-09

Geographic coverage: United States, Kentucky

Time period: 2013-01-01--2016-01-01

This study consists of a two-group, randomized, controlled comparative effectiveness trial with 300 individuals from Appalachian Kentucky who do not have a primary care provider (and thus are not able to receive the standard of care without intercession) and who are at risk for CVD (cardiovascular disease) by virtue of having two or more modifiable CVD risk factors. The researchers compared (1) the standard of care alone, referral to a primary care provider for management of CVD risk factors, with (2) standard of care supplemented by patient-centered, culturally appropriate, self-care CVD risk reduction intervention (HeartHealth) designed to improve multiple CVD risk factors while overcoming barriers to success.

The researchers compared the 4 month (short-term) and 1 year (long-term) impact of the interventions on: 1) CVD risk factors selected by patients (i.e., tobacco use, blood pressure, lipid profile, HgA1c for diabetics, body mass index, waist circumference, depressive symptoms, or physical activity level); 2) all CVD risk factors for each patient; 3) quality of life; 4) patient and healthcare provider satisfaction; 5) desirability and adoptability by assessing adherence to recommended CVD risk reduction protocols, and retention of recruited individuals.

Demographic variables include gender, age, ethnicity, marital status, employment status, and level of education.