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Curated

Comparing Two Ways to Manage Symptoms for Patients Who Have Chronic Migraine and Frequent Medication Use (The MOTS Trial), United States, 2017-2020 (ICPSR 38546)

Released/updated on: 2022-12-14

Geographic coverage: United States

Time period: 2017-02-20--2020-12-22

The Medication Overuse Treatment Strategy (MOTS) research trial sought to understand the relationship between individuals who suffer from chronic migraines and their use (or overuse) of medications to treat their migraines. A diagnosis of chronic migraines means that a person experiences headaches on 15 days or more per month with at least 8 of those days meeting the diagnostic criteria for migraine with or without aura. Of the nearly 7 million individuals in the United States who suffer from chronic migraines more than half of them overuse medication intended to relieve the symptoms. However, that overuse can bring about other medical issues. This research trial enrolled 720 chronic migraine sufferers from 34 clinics across the country. The subjects were randomized into two groups. A total of 361 patients were randomized to the treatment strategy that included migraine-preventive therapy with switching off the overused medication to an alternative used with a limited frequency, while 359 patients were randomized to migraine-preventive medication with continuation of the overused medication with no maximum limit.

Curated

Strategies to Assist with Management of Pain (STAMP), Wisconsin, Massachusetts, Utah, 2017-2024 (ICPSR 39154)

Released/updated on: 2026-04-22

Geographic coverage: United States, Massachusetts, Utah, Wisconsin

Time period: 2017-01-01--2024-01-01

Chronic low back pain is a leading cause of disability and reduced quality of life for nearly 100 million individuals in the United States. Approximately 5 to 10 percent of these individuals are prescribed opioids for treating their chronic low back pain. Limited data exists on the long-term efficacy of opioid treatment while much concern exists regarding the harm they can do to a person. Despite medication treatment patients still suffer from inadequate pain relief, impaired function, and quality of life.

This study sought to compare the long-term effectiveness of two types of alternative therapy approaches - mindfulness based therapy (MBT) and cognitive behavioral therapy (CBT) - for treating chronic low back pain especially those being treated by opioids.