Comparative Evaluation of Low- and High-Resolution Mass Spectrometric Approaches for Screening and Confirmation of New Psychoactive Substances in Human Specimen Matrices, 2022-2025 (ICPSR 39823)
Principal Investigator(s): View help for Principal Investigator(s)
Anthony P. DeCaprio, Florida International University
This is an external resource to which ICPSR links as a courtesy. These data are not available from ICPSR. Users should consult the data owners (via Comparative Evaluation of Low- and High-Resolution Mass Spectrometric Approaches for Screening and Confirmation of New Psychoactive Substances in Human Specimen Matrices, 2022-2025) directly for details on obtaining these resources.
Summary View help for Summary
New psychoactive substances (NPS) are emerging compounds that are analogs or derivatives of controlled substances and marketed as "legal highs" to evade law enforcement regulations. The most promising current approach to comprehensive screening and confirmation of NPS in forensic toxicology is analysis by liquid chromatography (LC) with mass spectrometric (MS) detection. This project performed side-by-side evaluations of targeted screening analyses for NPS by LC-QqQ-MS compared to LC-QTOF-MS and of untargeted analyses by LC-QTOF-MS compared to LC-Q-Orbitrap-MS. These comparisons were conducted using three important human specimen matrices: urine, whole blood, and oral fluid. The effectiveness of rapid sample preparation for both targeted and nontargeted screening was also demonstrated. Applicability of the MS workflows was confirmed by screening of authentic urine from a drug testing laboratory.