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In 1995-1996, the MacArthur Midlife Research Network carried out a national survey of over 7,000 Americans aged 25 to 74 (ICPSR 2760). The purpose of the study was to investigate the role of behavioral, psychological, and social factors in understanding age-related differences in physical and mental health.

With support from the National Institute on Aging, an initial follow-up of the original Midlife Development in the United States (MIDUS) samples was conducted in 2004 (MIDUS 2). The daily stress and cognitive functioning projects were repeated at MIDUS 2; in addition the protocol was expanded to include biomarkers and neuroscience. In 2005, a baseline sample of 592 African Americans from Milwaukee was added to MIDUS to examine health issues in minority populations.

In 2013, a third wave (MIDUS 3) of survey data was collected on longitudinal participants. Data collection for this follow-up wave largely repeated baseline assessments (e.g., phone interview and extensive self-administered questionnaire), with additional questions in selected areas (e.g., economic recession experiences, optimism and coping, stressful life events, and caregiving). A third wave of cognitive functioning data and a second wave of the Milwaukee sample were also collected. Data collection for the daily diary, biomarkers, and neuroscience is ongoing. This dataset includes all known MIDUS decedents (N=2,533) from the Core National and Milwaukee samples as of December 2023.

The Midlife in the United States (MIDUS) is a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. A description of the study and findings from it are available at http://www.midus.wisc.edu.

The first wave of the MIDUS study (MIDUS 1 or M1) collected survey data from a total of 7,108 participants. The baseline sample was comprised of individuals from four subsamples: (1) a national RDD (random digit dialing) sample (n=3,487); (2) oversamples from five metropolitan areas in the U.S. (n=757); (3) siblings of individuals from the RDD sample (n=950); and (4) a national RDD sample of twin pairs (n=1,914). All eligible participants were non-institutionalized, English-speaking adults in the coterminous United States, aged 25 to 74.

Data from the samples were collected primarily in 1995/96. The survey (Project 1) dataset contains responses from a 30-minute Phone interview and two 50-page Self-Administered Questionnaire (SAQ) instruments. Of the 7,108 respondents who completed the Phone interview, 6,325 also completed the SAQ.

This updated version of the study is comprised of three primary datasets:

Dataset 1, Main, Siblings, and Twin Data, contains responses from the main survey of 7,108 respondents. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. Those queried were asked to describe their histories of physical ailments, including heart-related conditions and cancer, as well as the treatment and/or lifestyle changes they went through as a result. A series of questions addressed alcohol, tobacco, and illegal drug use, and focused on history of use, regularity of use, attempts to quit, and how the use of those substances affected respondents' physical and mental well-being. Additional questions addressed respondents' sense of control over their health, their awareness of changes in their medical conditions, commitment to regular exercise and a healthy diet, experience with menopause, the decision-making process used to deal with health concerns, experiences with nontraditional remedies or therapies, and history of attending support groups. Respondents were asked to compare their overall well-being with that of their peers and to describe social, physical, and emotional characteristics typical of adults in their 20's, 40's, and 60's. Information on the work histories of respondents and their significant others was also elicited, with items covering the nature of their occupations, work-related physical and emotional demands, and how their personal health had correlated to their jobs. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were also asked to consider their personal feelings of accomplishment, desire to learn, sense of control over their lives, interests, and hopes for the future.

The Datasets previously numbered 2 and 3 have been removed to avoid redundancies, and all datasets have been renumbered. Please refer to the readme file.

Dataset 2, Twin Screener Data, provides the first national sample of twin pairs ascertained randomly via the telephone.

Dataset 3, Coded Text Responses, describes how open-ended textual responses in the MIDUS 1 Computer-Assisted Telephone Interview (CATI) and Self-Administered Questionnaire (SAQ) were transformed into categorical numeric codes. These codes are included in a stand-alone dataset containing only those cases (N=3,950) that contained text data in their responses.

Online Analysis Only: Datasets 1, 2, and 3 were merged together by the SU_ID variable to form "Merged Data with Weights (Online Analysis Only)" (Dataset 4) for online analysis capabilities.

MIDUS also maintains a Colectica portal, which allows users to interact with variables across waves and create customized subsets. Registration is required.

In 1995-1996, the MacArthur Midlife Research Network carried out a national survey of 7,108 Americans aged 25 to 74 (MIDLIFE IN THE UNITED STATES (MIDUS), 1995-1996 [ICPSR 2760]). The purpose of the study was to investigate the role of behavioral, psychological, and social factors in understanding age-related differences in physical and mental health. The study was innovative for its broad scientific scope, its diverse samples (which included twins and the siblings of main sample respondents), and its creative use of in-depth assessments in key areas (e.g., daily stress and cognitive functioning). A description of the study and findings from it are available at http://www.midus.wisc.edu. With support from the National Institute on Aging, a longitudinal follow-up of the original MIDUS samples: core sample (N = 3,487), metropolitan over-samples (N = 757), twins (N = 925 complete pairs), and siblings (N = 950), was conducted in 2004-2006. Guiding hypotheses for it, at the most general level, were that behavioral and psychosocial factors are consequential for physical and mental health. MIDUS 2 respondents were aged 35 to 86. Data collection largely repeated baseline assessments (e.g., phone interview and extensive self-administered questionnaire), with additional questions in selected areas (e.g., cognitive functioning, optimism and coping, stressful life events, and caregiving). To add refinements to MIDUS 2, an African American sample (N = 592) was recruited from Milwaukee, Wisconsin, who participated in a personal interview and completed a questionnaire paralleling the above assessments. Survey data for the Milwaukee sample are available in a separate project [ICPSR 22840]. Also administered was a modified form of the mail questionnaire, via telephone, to respondents who did not complete a self-administered questionnaire.

In 1994/1995, the MacArthur Midlife Research Network carried out a national survey of over 7,000 Americans aged 25 to 74. The purpose of the study was to investigate the role of behavioral, psychological, and social factors in understanding age-related differences in physical and mental health. A description of the study and findings from it are available at the MIDUS website.

With support from the National Institute on Aging, a longitudinal follow-up of the original MIDUS samples (core sample (N = 3,487), metropolitan over-samples (N = 757), twins (N = 957 pairs), and siblings (N = 950)) was conducted in 2004-2006. Guiding hypotheses, at the most general level, were that behavioral and psychosocial factors are consequential for health (physical and mental). The purpose of the Cognitive Project was to determine how cognition is related to overall mental and physical health. Specific goals were: (1) to characterize the nature and range of midlife cognitive performance, relative to those younger and older, across multiple domains in a nationally representative sample (MIDUS); and (2) to examine the relationship between biopsychosocial factors (e.g., SES, health status, health-promoting behaviors, metabolic and cardiovascular biomarkers, depression, personality, control beliefs, stressful life events) and individual differences in cognitive functioning.

The development of a cognitive battery for the second wave of testing of the Midlife Development in the United States (MIDUS) study provided an opportunity to examine the cognitive performance of young, middle-aged and older adults from a wide range of education levels in a large-scale, national sample. As part of the Cognitive Project of the MIDUS II the Brief Test of Adult Cognition by Telephone (BTACT) (Lachman & Tun, 2008; Tun & Lachman, 2006) was administered. More information about the BTACT can be found at the Brandeis website. The BTACT represents the first comprehensive cognitive battery, including measures of speed and reaction time, to be administered by telephone to a national sample across the adult years and into later life. With a response rate of over 86 percent for the cognitive testing component of the MIDUS II, a cognitive data set of unprecedented range in terms of age, gender, socioeconomic status (SES), education, and geographic diversity was produced.

The Neuroscience study is Project 5 of the MIDUS longitudinal study, a national survey of more than 7,000 Americans (aged 25 to 74) begun in 1994. The purpose of the larger study was to investigate the role of behavioral, psychological, and social factors in understanding age-related differences in physical and mental health. With support from the National Institute on Aging, a longitudinal follow-up of the original MIDUS samples [core sample (N = 3,487), metropolitan over-samples (N = 757), twins (N = 957 pairs), and siblings (N = 950)] was conducted in 2004-2006.

The Neuroscience Project of MIDUS 2 contains data from 331 respondents. These respondents include two distinct subsamples, all of whom completed both the Project 1 Survey and the Project 4 biomarker assessment at University of Wisconsin-Madison: (1) longitudinal (n = 223) and (2) Milwaukee (n = 108). The Milwaukee group contained individuals who participated in the baseline MIDUS Milwaukee study, initiated in 2005.

The purpose of the Neuroscience Project was to examine the central circuitry associated with individual differences in affective style that represent a continuum from vulnerability to resilience, and characterize some of the peripheral consequences of these central profiles for biological systems that may be relevant to health. The primary aims were to: (1) characterize individual differences in both emotional reactivity and emotional recovery using psychophysiological measures such as corrugator electromyography and eyeblink startle magnitude, (2) characterize individual differences in brain morphology, in particular amygdala and hippocampal volume, using structural magnetic resonance imaging (MRI), (3) characterize individual differences in activity within the neural circuitry of emotion regulation using both electroencephalography and fMRI, and (4) test the ability of the central indices in this project to predict the comprehensive array of health, cognitive, psychological, social, and life challenge factors assessed in the other MIDUS projects.

To probe individual differences in emotional reactivity and recovery (a key component of regulation) the Neuroscience Project examined both psychophysiological and fMRI measures during the presentation of emotional (positive and negative) and neutral pictures, and these same measures during a post-picture period. The logic of this strategy is that continued activation during the recovery period following a negative stimulus is indicative of poor automatic emotion regulation. Respondents in the Neuroscience Project are a representative subsample of the MIDUS (Midlife in the United States) survey.

National respondents in the Neuroscience Project are a representative subsample of the MIDUS 2 survey sample (#4652).

The raw neuro-imaging data are not available through NACDA/ICPSR; please see the README file for more information about how to obtain them.

From 2004-2009, an initial follow-up of the original Midlife Development in the United States samples (MIDUS 2) was conducted with expansion of the protocol to include Neuroscience Project data collection and a sample of Black Americans from Milwaukee, WI. The MIDUS Neuroscience Project performed a second follow-up from 2017-2022 of the MIDUS Main and Milwaukee samples (MIDUS 3) on a subsample of those who completed the MIDUS 3 Survey and Biomarker Projects.

The goal was to examine indices of brain aging, function, and structure with a focus on the brain circuitry associated with individual differences in affective style, and to characterize the peripheral consequences of these central profiles for biological systems that may be relevant to health. The primary aims were to: (1) characterize individual differences in emotional reactivity, recovery, and sustaining processes using corrugator and zygomatic electromyography and eyeblink startle magnitude, (2) characterize individual differences in brain morphology and connectivity using structural magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) (3) characterize individual differences in functional activity within the neural circuitry of emotion using task and resting state fMRI, (4) calculate brain age, and (5) test the ability of these indices to predict the comprehensive array of health, wellbeing, cognitive, psychological, social, and life challenge factors assessed in other MIDUS projects. To probe individual differences in emotional processes, psychophysiological and fMRI measures of emotional responses to the presentation of negative, positive, and neutral pictures, and these same measures during a post-picture period were examined.

Emotion-influenced memory was assessed at both the psychophysiological and imaging sessions: (1) Free recall of the presented affective pictures at the end of the psychophysiological session. (2) Memory and likeability ratings for neutral faces paired with the affective pictures in the imaging task. Finally, selected tasks from the CANTAB assessed affective biases and cognitive processes important for emotion regulation.

In 2008, with funding from the National Institute on Aging (NIA), baseline survey data for the Survey of Midlife in Japan (MIDJA), April-September 2008 were collected from a probability sample of Japanese adults (N=1,027) aged 30 to 79 from the Tokyo metropolitan area (ICPSR 30822). In 2009-2010 biomarker data was obtained from a subset of these cases (ICPSR 34969).

The survey and biomarker measures obtained parallel those in a national longitudinal sample of Americans known as Midlife in the United States or MIDUS (ICPSR 2760: MIDUS 1 and ICPSR 4652: MIDUS 2). The central objective was to compare the Japanese sample (MIDJA) with the United States sample (MIDUS) to test hypotheses about the role of psychosocial factors in the health (broadly defined) of mid- and later-life adults in Japan and the United States.

In 2012, with additional support from NIA, a longitudinal follow-up of the MIDJA sample was completed. The data collection for this second wave (N=657) largely repeated the baseline assessments. The goal of the follow-up wave was to conduct comparisons of longitudinal data available from the Japanese sample (MIDJA) and the United States sample (MIDUS) to test the hypothesis about the role of psychosocial factors in predicting health changes (including biomarkers) in both cultural contexts. Cultural influences on age differences in health and well-being were also of interest.

Demographic and background information included gender, age, education, marital status, household composition, and income.