Midlife in the United States (MIDUS 3): Biomarker Project, 2017-2022 (ICPSR 38837)
Version Date: Nov 14, 2023 View help for published
Principal Investigator(s): View help for Principal Investigator(s)
Carol D. Ryff, University of Wisconsin-Madison;
Teresa E. Seema, University of California-Los Angeles;
Maxine Weinstein, Georgetown University
https://doi.org/10.3886/ICPSR38837.v1
Version V1
Alternate Title View help for Alternate Title
Summary View help for Summary
The Biomarker Project is one of multiple projects that comprise the MIDUS 3 (M3) "Integrative Pathways to Health and Illness" study. For the past two decades, the overarching objective of MIDUS has been to investigate linkages between sociodemographic, psychosocial, behavioral, and neurobiological variables to account for unfolding profiles of morbidity and mortality across the decades of adult life as well as the maintenance of good health and functional capacities. The study has facilitated analyses that pay attention simultaneously to age, gender, race, and socioeconomic variation in how psychosocial and neurobiological variables are linked. In addition, the M3 data permit longitudinal assessment of the impact of ongoing historical events, such as the 2008 economic recession, on the health of diverse-aged adults, which was also included in the MIDUS Refresher 1 (MR1) assessments. M3 included recruitment of additional twins to facilitate genomic analysis.
The M3 Biomarker Project (P4) includes assessment of multiple indicators of physiological regulation/dysregulation and health according to the basic protocol implemented in the MR1 study, which repeated and expanded the M2 biomarker protocol. The M3 protocol included bone density and body composition assessments at all sites and expansion of Actigraphy, Ankle Brachial Index (ABI) and Gait assessments to all three sites. Data were collected during a 24-hour stay at one of three Clinical Research Units (CRU).
Citation View help for Citation
Export Citation:
Funding View help for Funding
Subject Terms View help for Subject Terms
Smallest Geographic Unit View help for Smallest Geographic Unit
Other
Distributor(s) View help for Distributor(s)
Time Period(s) View help for Time Period(s)
Date of Collection View help for Date of Collection
Data Collection Notes View help for Data Collection Notes
-
The M3 dataset uses the M2ID variable to identify individual respondents. This variable can be used to merge any MIDUS datasets derived from the original longitudinal sample.
-
Due to pandemic-related interruptions in data collection, the M3 field period was extended from April 2017 to May 2022.
- The uploaded materials are already available to the public freely via the MIDUS Colectica Portal.
Study Purpose View help for Study Purpose
The purpose of the Biomarker Project was to add comprehensive biological assessments on a subsample of MIDUS respondents, thus facilitating analyses that integrate behavioral and psychosocial factors with biology. The broad aim is to identify biopsychosocial pathways that contribute to diverse health outcomes. A further theme is to investigate protective roles that behavioral and psychosocial factors have in delaying morbidity and mortality, or in fostering resilience and recovery from health challenges once they occur. The research was not disease-specific, given that psychosocial factors have relevance across multiple health endpoints.
Study Design View help for Study Design
Biomarker data collection was carried out at three General Clinical Research Centers (at UCLA, University of Wisconsin-Madison, and Georgetown University). The biomarkers reflect functioning of the hypothalamic-pituitary-adrenal axis, the autonomic nervous system, the immune system, cardiovascular system, musculoskeletal system, antioxidants, and metabolic processes. Specimens (fasting blood draw, 12-hour urine, saliva) allow for assessment of multiple indicators within these major systems. The protocol also included assessments by clinicians or trained staff, including vital signs, morphology, functional capacities, bone densitometry, medication usage, and a physical exam. Project staff obtained indicators of heart-rate variability, beat to beat blood pressure, respiration, and salivary cortisol assessments during an experimental protocol that included both a cognitive and orthostatic challenge. To augment the self-reported data collected in Project 1, participants completed a medical history, self-administered questionnaire, and self-reported sleep assessments. For respondents at one site (UW-Madison), objective sleep assessments were also obtained with an Actiwatch(R) activity monitor.
Sample View help for Sample
The MIDUS 3 Biomarker Project contains data from 747 respondents. These respondents include two distinct subsamples, all of whom completed the MIDUS 3 Survey Project: (1) longitudinal survey sample (n = 644) and (2) Milwaukee sample (n = 103). The Milwaukee group contained individuals who participated in the MIDUS Milwaukee 2 study.
Time Method View help for Time Method
Universe View help for Universe
Respondents who completed the MIDUS 3 Survey Project longitudinal survey sample and Milwaukee sample. The Milwaukee group contained individuals who participated in the MIDUS Milwaukee 2 study.
Unit(s) of Observation View help for Unit(s) of Observation
Data Type(s) View help for Data Type(s)
Mode of Data Collection View help for Mode of Data Collection
Response Rates View help for Response Rates
Overall Rate: 747/1266 = 59% (Eligible = living, healthy enough to travel safely)
Adjusted Rate: 747/1162 = 64.3% (Eligible excludes: No contact/Unable to locate)
Presence of Common Scales View help for Presence of Common Scales
- Pittsburgh Sleep Quality (PSQ)
- Mood and Symptom Questionnaire (MASQ)
- Center for Epidemiological Studies Depression Inventory (CES-D)
- Perceived Stress Scale-10 Item Version (PSS)
- Spielberger Anger Expression Inventory
- Spielberger Trait Anger
- Spielberger Trait Anxiety Inventory
- Social Anxiety Scale
- Childhood Trauma Questionnaire (CTQ)
- Positive Events Scale
- Singelis Self-Construal Scale
- Social Obligation Scale
- Relational-Interdependent Self Construal Scale
- Sympathy Scale (Expanded)
- Adjustment Scale
- Support and Strain Given to Friends Scale
- Friendship Support
- Support Given to Family Scale
- Support Given to Spouse Scale
- Self-Control Scale
- Subjective Well-Being Scale
- UCLA Loneliness Scale
- Subjective Well-Being: Japanese Comparison Scale
- Symptoms and Conditions
- Counts of Health Events
- MIDUS Healthy Eating Index
- Family Medical History
- Metabolic Equivalent of Task (MET)
- Marital Status
- Counts of Intervening Events
- Medication Use
- Body Indices
Additional information regarding scales can be found in the Psychosocial Constructs and Composite Variables documentation.
HideOriginal Release Date View help for Original Release Date
2023-11-14
Version History View help for Version History
2023-11-14 ICPSR data undergo a confidentiality review and are altered when necessary to limit the risk of disclosure. ICPSR also routinely creates ready-to-go data files along with setups in the major statistical software formats as well as standard codebooks to accompany the data. In addition to these procedures, ICPSR performed the following processing steps for this data collection:
- Checked for undocumented or out-of-range codes.
Weight View help for Weight
The data are not weighted and no weight variables are present in the dataset.
HideNotes
The public-use data files in this collection are available for access by the general public. Access does not require affiliation with an ICPSR member institution.
This study is maintained and distributed by the National Archive of Computerized Data on Aging (NACDA), the aging program within ICPSR. NACDA is sponsored by the National Institute on Aging (NIA) at the National Institutes of Heath (NIH).