Search results

This study is part of the Seek, Test, Treat and Retain (STTR) Collaboration Project that involved over twenty studies in the fields of HIV and drug abuse. All studies were independently developed, but were chosen for the collaboration because they focused on one or more steps of the HIV treatment cascade: Seek, Test, Treat and Retain. As part of STTR Collaboration Project, the studies were grouped into Criminal Justice-related studies and Vulnerable Population-related studies. The data collected by these studies included twelve common domains (e.g., Demographic characteristics, Mental Health) in each of which a shared questionnaire or instrument was taken up by the studies and adapted to fit the study.

The main project of the CARE+ Corrections study is in Washington DC and is a RCT evaluating the "CARE+ Corrections intervention (a computerized tool integrating HIV treatment counseling, secondary transmission risk reduction counseling, and facilitated linkage to care through text message reminders)" versus standard of care among returning citizens in Washington, DC. The study is recruiting 100 participants who are incarcerated or were released from a correctional facility less than 6 months ago.

This study is part of the Seek, Test, Treat and Retain (STTR) Collaboration Project that involved over twenty studies in the fields of HIV and drug abuse. All studies were independently developed, but were chosen for the collaboration because they focused on one or more steps of the HIV treatment cascade: Seek, Test, Treat and Retain. As part of STTR Collaboration Project, the studies were grouped into Criminal Justice-related studies and Vulnerable Population-related studies. The data collected by these studies included twelve common domains (e.g., Demographic characteristics, Mental Health) in each of which a shared questionnaire or instrument was taken up by the studies and adapted to fit the study.

The specific aim for this study was to conduct a placebo-controlled, RCT of VIVITROL or (extended-release naltrexone) (XR-NTX 380mg) among HIV+ persons in jails and prisons meeting DSM-IV criteria for opioid dependence who are transitioning to the community. HIV treatment outcomes (HIV-1 RNA levels, CD4 count, HAART adherence, retention in care), substance abuse (time to relapse to opioid use, % opioid negative urines, opioid craving), adverse side effects and HIV risk behavior (sexual and drug-related risks) outcomes were compared in 150 recruited prisoners and jail detainees in CT and MA who were randomized 2:1 to either XR-NTX 380mg or XR-NTX-placebo. The primary outcome of interest was the proportion with a HIV-RNA less than 400 copies/mL at 6 months. Secondary outcomes included mean CD4 count, antiretroviral adherence, retention on HAART and in HIV care, HIV risk behaviors, time-to-relapse to opioid use, percent opioid negative urines, retention on XR-NTX 380mg and HIV quality of life. Primary and secondary outcomes were assessed for an additional 6 months after completion of the intervention.