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The Biomarker study is Project 4 of the Midlife in the United States (MIDUS) longitudinal study, a national survey of more than 7,000 Americans (aged 25 to 74) begun in 1994. The purpose of the larger study was to investigate the role of behavioral, psychological, and social factors in understanding age-related differences in physical and mental health. With support from the National Institute on Aging (NIA), a longitudinal follow-up of the original MIDUS samples [core sample (N = 3,487), metropolitan over-samples (N = 757), twins (N = 957 pairs), and siblings (N = 950)] was conducted in 2004-2006. Guiding hypotheses, at the most general level, were that behavioral and psychosocial factors are consequential for health (physical and mental). A description of the study and findings from it are available on the MIDUS website.

The Biomarker Project (Project 4) of MIDUS 2 contains data from 1,255 respondents. These respondents include two distinct subsamples, all of whom completed the Project 1 Survey: (1) longitudinal survey sample (n = 1,054) and (2) Milwaukee sample (n = 201). The Milwaukee group contained individuals who participated in the baseline MIDUS Milwaukee study, initiated in 2005. The purpose of the Biomarker Project (Project 4) was to add comprehensive biological assessments on a subsample of MIDUS respondents, thus facilitating analyses that integrate behavioral and psychosocial factors with biology. The broad aim is to identify biopsychosocial pathways that contribute to diverse health outcomes. A further theme is to investigate protective roles that behavioral and psychosocial factors have in delaying morbidity and mortality, or in fostering resilience and recovery from health challenges once they occur. The research was not disease-specific, given that psychosocial factors have relevance across multiple health endpoints.

Biomarker data collection was carried out at three General Clinical Research Centers (at UCLA, University of Wisconsin, and Georgetown University). The biomarkers reflect functioning of the hypothalamic-pituitary-adrenal axis, the autonomic nervous system, the immune system, cardiovascular system, musculoskeletal system, antioxidants, and metabolic processes. Our specimens (fasting blood draw, 12-hour urine, saliva) allow for assessment of multiple indicators within these major systems. The protocol also included assessments by clinicians or trained staff, including vital signs, morphology, functional capacities, bone densitometry, medication usage, and a physical exam. Project staff obtained indicators of heart-rate variability, beat to beat blood pressure, respiration, and salivary cortisol assessments during an experimental protocol that included both a cognitive and orthostatic challenge. Finally, to augment the self-reported data collected in Project 1, participants completed a medical history, self-administered questionnaire, and self-reported sleep assessments. For respondents at one site (UW-Madison), objective sleep assessments were also obtained with an Actiwatch(R) activity monitor.

The MIDUS Refresher study Survey (2011-2014 ICPSR 36532) recruited a national probability sample of 3,577 adults, aged 25 to 74, designed to replenish the original MIDUS 1 baseline cohort and paralleling the five decadal age groups of the MIDUS 1 baseline survey (ICPSR 2760). The MIDUS Refresher survey employed the same comprehensive assessments as those assembled on the core longitudinal MIDUS sample, but with additional questions about impacts of the economic recession of 2008-09. The MIDUS Refresher Biomarker study (2012-2016) obtained data from 863 respondents (n=746 Main sample, n=117 African Americans from Milwaukee) who completed the MIDUS Refresher Survey.

The purpose of the Refresher Biomarker Project (Project 4) parallels that of the MIDUS 2 Biomarker project (ICPSR 29282), which collected comprehensive biological assessments on a subsample of MIDUS respondents, thus facilitating analyses that integrate behavioral and psychosocial factors with biological regulation/dysregulation, broadly defined. The aim was to use such data to explicate biopsychosocial pathways that contributed to diverse health outcomes. A further theme was to examine period effects on health (mental and physical) related to the economic recession by comparing the pre-recession MIDUS sample with the post-recession MIDUS Refresher sample. A further objective of the MIDUS Refresher sample was to strengthen cross-project analyses by increasing the sample sizes available for testing hypotheses regarding the interplay of key factors (e.g., socioeconomic status, gender, psychosocial factors, biological factors) in mid- and later-life health.

Biomarker data collection was carried out at hypothalamic-pituitary-adrenal axis, the autonomic nervous system, the immune system, cardiovascular system, musculoskeletal system, antioxidants, and three General Clinical Research Centers (at UCLA, University of Wisconsin, and Georgetown University). The biomarkers reflect functioning of the metabolic processes. Our specimens (fasting blood draw, 12-hour urine, saliva) allowed for assessment of multiple indicators within these major systems. The protocol also included assessments by clinicians or trained staff, including vital signs, morphology, functional capacities including 3 dimensional gait analysis, bone densitometry, body composition, ankle brachial index, medication usage, and a physical exam. Project staff obtained indicators of heart-rate variability, beat to beat blood pressure, respiration, and salivary cortisol assessments during an experimental protocol that included both a cognitive and orthostatic challenge. Finally, to augment the self-reported data collected in Survey (Project 1), participants completed a medical history, self-administered questionnaire, and self-reported sleep assessments. For respondents at one site (UW-Madison), objective sleep assessments were also obtained with an Actiwatch(R) activity monitor.

This survey of 12th-grade students is part of a series that explores changes in important values, behaviors, and lifestyle orientations of contemporary American youth. Students are randomly assigned to complete one of six questionnaires, each with a different subset of topical questions, but all containing a set of "core" questions on demographics and drug use. There are about 1,400 variables across the questionnaires. Drugs covered by this survey include tobacco, smokeless tobacco, alcohol, marijuana, hashish, prescription medications, over-the-counter medications, LSD, hallucinogens, amphetamines (stimulants), Ritalin (methylphenidate), Quaaludes (methaqualone), barbiturates (tranquilizers), cocaine, crack cocaine, GHB (gamma hydroxy butyrate), ecstasy, methamphetamine, and heroin. Other topics include attitudes toward religion, changing roles for women, educational aspirations, self-esteem, exposure to drug education, and violence and crime (both in and out of school).

Highlights for 2021:

• Data collection resumed in 2021, with a change to all web-based surveys.
• Students completed the surveys on their personal or school-provided device.
• Non-survey variables have been changed or added to facilitate analyses. For details, please see the codebook section "MTF Variable Information - Non-survey variables included in the data files - Survey mode and design variables for 2021"
• Information about "screen break" issues, where series of questions were originally presented differently in the web-based survey as compared to the 2019/2020 tablet surveys. Please see the codebook and Appendix D for details.
• For 12th grade: two additional changes to the survey presentation. Please see the codebook section "MTF Variable Information - Non-survey variables included in the data files", and respective appendices for details.
• Introduction of randomized blocks of questions presented to students. Please see Appendix E.
• Test of presentation of items in the substance use consequences section on form 3. Please see Appendix F.
• Additional information is documented in the MTFQchanges2021byForm.pdf and MTFQchanges2021byType.pdf files available for download.

This survey of 12th-grade students is part of a series that explores changes in important values, behaviors, and lifestyle orientations of contemporary American youth. Students are randomly assigned to complete one of six questionnaires, each with a different subset of topical questions, but all containing a set of "core" questions on demographics and drug use. There are about 1,400 variables across the questionnaires. Drugs covered by this survey include tobacco, smokeless tobacco, alcohol, marijuana, hashish, prescription medications, over-the-counter medications, LSD, hallucinogens, amphetamines (stimulants), Ritalin (methylphenidate), Quaaludes (methaqualone), barbiturates (tranquilizers), cocaine, crack cocaine, GHB (gamma hydroxy butyrate), ecstasy, methamphetamine, and heroin. Other topics include attitudes toward religion, changing roles for women, educational aspirations, self-esteem, exposure to drug education, and violence and crime (both in and out of school).

Highlights for 2022:

• Continuation of randomized blocks of questions presented to students. Please see Appendix D of the codebook.
• Change to the question stem for some lifetime, 12 month, and 30 day heroin and marijuana use questions. Please see the Highlights for 2022 section in the codebook for more details.
• Change to the heroin use questions: Separate questions about heroin use with a needle and heroin use without a needle for lifetime, past 12 months, and past 30 day timeframes are no longer asked. The separate questions have been replaced by the single question, "On how many occasions (if any), have you taken heroin...
  • ...in your lifetime?
  • ...during the last 12 months?
  • ...during the last 30 days?

Additional information is documented in the MTFQchanges2022byForm.pdf and MTFQchanges2022byType.pdf files available for download.

This survey of 12th-grade students is part of a series that explores changes in important values, behaviors, and lifestyle orientations of contemporary American youth. Students are randomly assigned to complete one of six questionnaires, each with a different subset of topical questions, but all containing a set of "core" questions on demographics and substance use. There are about 1,400 variables across the questionnaires. Substance use covered by this survey includes: tobacco, smokeless tobacco, alcohol, marijuana, hashish, vaping, prescription medications, over-the-counter medications, LSD, hallucinogens, amphetamines (stimulants), Ritalin (methylphenidate), sedatives/barbiturates (tranquilizers), cocaine, crack cocaine, GHB (gamma hydroxy butyrate), ecstasy, methamphetamine, and heroin. Other topics include attitudes toward religion, changing roles for women, educational aspirations, self-esteem, exposure to drug education, and violence and crime (both in and out of school).

Highlights for 2023:

• 12th grade only: Continuation of randomized blocks of questions presented to students. Please see Appendix D of the codebook.
• All grades: Change to the question stem for some lifetime, 12 month, and 30 day marijuana use questions.
• Separate codebooks are generated by ICPSR for the core data file (DS1) and the six form-specific data files (DS2-DS7). The codebooks contain only the frequencies, question text, and response options for the survey items. Please see the documentation under DS0 Study-Level Files for the annual study documentation provided by MTF, 39172-0001-User_guide-UsersGuide.pdf.

Please see the Highlights for 2023 section in the codebook for more details.

Additional information is documented in the MTFQchanges2023byForm.pdf and MTFQchanges2023byType.pdf files available for download.

This survey of 12th-grade students is part of a series that explores changes in important values, behaviors, and lifestyle orientations of contemporary American youth. Students are randomly assigned to complete one of six questionnaires, each with a different subset of topical questions, but all containing a set of "core" questions on demographics and substance use. There are about 1,400 variables across the six questionnaires. Substance use covered by these surveys includes tobacco, smokeless tobacco, alcohol, marijuana/cannabis, prescription medications, over-the-counter medications, inhalants, steroids, LSD and other hallucinogens, amphetamines (stimulants), sedatives/barbiturates, tranquilizers, cocaine, crack cocaine, ecstasy, methamphetamine, heroin, narcotics other than heroin, and vaping of nicotine, marijuana/cannabis, and flavors. Other topics include attitudes toward religion, changing roles for women, educational aspirations, self-esteem, exposure to drug education, and violence and crime (both in and out of school).

Highlights for 2024:

• The MTF sampling procedure was updated in 2024. Please see the 2024 MTF annual report for details. Variable-specific details are found in the user's guide that accompanies this study.
• Continuation of randomized blocks of questions presented to students. Please see Appendix D of the user's guide.
• In 2023, the question about use of Delta-8 THC was included only on forms 3 and 6. In 2024, this question is now included on all survey forms. With the inclusion on all forms, please note these variable name changes:
  • CORE: V2934 was changed to V7976
  • Form 3: V3660 was changed to V7976
  • Form 6: V6676 was changed to V7976
• Changes were made to the question stems for many of the substance use "triplets", i.e. lifetime, 12 month, and 30 day timeframes, including: marijuana/cannabis, hallucinogens other than LSD, amphetamines (stimulants), sedatives/barbiturates, tranquilizers, and narcotics other than heroin.
• Additional information about question text and response option changes, along with details about added and dropped questions, are documented in the MTFQchanges2024byForm.pdf and MTFQchanges2024byType.pdf files available for download.
• MTF is no longer providing dichotomized substance use variables on the DS1 datasets. As each researcher has their own method of working with data, it is up to the researcher to create these variables for their specific needs.