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Substance dependence (SD) is a chronic disease that requires specialty drug and alcohol treatment, primary care (PC), and management of related problems. Although patients with SD may be linked with specialty care and PC, their health care often remains episodic and fragmented, rather than longitudinal, comprehensive, integrated, and coordinated. As a result, adults with SD often enter addiction treatment later and require acute medical care, rather than entering the system earlier when interventions of lower intensity but longer duration might prevent catastrophes. Chronic disease management (CDM) is a collaborative, longitudinal approach to treatment of certain chronic medical illnesses proven to be more effective than routine care. CDM addresses individual patient and health systems barriers to receipt of needed treatment. However, the effectiveness of CDM for SD has not been tested. The objective of this Addiction Health Evaluation and Disease management (AHEAD) study, was to test the effectiveness of CDM for SD in PC.

Subject identification and recruitment occurred primarily at a local detoxification center, as well as by self and physician referral from the Boston Medical Center primary and ambulatory care clinics, emergency department, urgent care center, inpatient settings, and the community. The study enrolled 320 adults with drug dependence and 320 adults with alcohol dependence who were not in SD treatment, and randomized them to a SD CDM program (the AHEAD Clinic) integrated into a real-world PC clinic or to referral to standard PC. All subjects were assessed regarding SD diagnosis, substance use and problems, readiness to change, health-related quality of life, and medical and drug treatment utilization. Subjects were evaluated 3, 6, and 12 months later, and health services utilization data were collected for 2 years from a statewide database. Additionally, in order to better understand and explain the implementation and fidelity of the AHEAD Clinic, the primary care providers (PCPs) of AHEAD Clinic patients were surveyed. Each PCP was presented with a letter from the Principal Investigator explaining the purpose of the survey, the reason why s/he was being asked to complete the survey, compensation for completing the survey, and details about confidentiality and anonymity. The survey itself consisted of questions asking providers about their satisfaction and their attitudes towards caring for patients with alcohol and drug problems, their knowledge of services that the AHEAD Clinic provides, and their experience working with the AHEAD Clinic.

Primary outcomes were illicit drug use, alcohol use, substance-related problems, emergency department visits, and hospitalizations. The proposal's hypothesis was that compared with standard care, a health services delivery intervention (CDM for SD integrated in PC) would decrease alcohol and illicit drug use and related problems, and improve health care utilization patterns. Improved outcomes using the AHEAD approach would support the adoption of a health services delivery strategy, CDM, to better care for patients with SD.

• Dataset 1: 844 variables; 563 cases
• Dataset 2: 607 variables; 500 cases
• Dataset 3: 607 variables; 487 cases
• Dataset 4: 713 variables; 532 cases
• Dataset 5: 80 variables; 549 cases
• Dataset 6: 59 variables; 1,435 cases
• Dataset 7: 25 variables; 87 cases
• Dataset 8: 25 variables; 87 cases
• Dataset 9: 41 variables; 73 cases
• Dataset 10: 9 variables; 11,018 cases
• Dataset 11: 5 variables; 511 cases

The California Families Project (CFP) is an ongoing longitudinal study of Mexican origin families in Northern California. This study uses community, school, family, and individual characteristics to examine developmental pathways that increase risk for and resilience to drug use in Mexican-origin youth. This study also examines the impact that economic disadvantage and cultural traditions have in Mexican-origin youth. The CFP includes a community-based sample of 674 families and children of Mexican origin living in Northern California, and includes annual assessments of parents and children. Participants with Mexican surnames were drawn at random from school rosters of students during the 2006-2007 and 2007-2008 school year. Data collection included multi-method assessments of a broad range of psychological, familial, scholastic, cultural, and neighborhood factors. Initiation of the research at age 10 was designed to assess the focal children before the onset of Alcohol, Tobacco, and Other Drug (ATOD) use, thus enabling the evaluation of how hypothesized risk and resilience mechanisms operate to exacerbate early onset during adolescence or help prevent its occurrence. This study includes a diversity of families that represent a wide range of incomes, education, family history, and family structures, including two-parent and single-parent families.

The accompanying data file consists of 674 family cases with each case representing a focal child and at least one parent (Two-parent: n=549, 82 percent; Single-parent: n=125, 18 percent). Of the 3,139 total variables, 839 pertain to the focal child, 1,376 correspond to the mother, and 908 items pertain to the father.

Please note: While the California Families Project is a longitudinal study, only the baseline data are currently available in this data collection.

This study is also available on the HEAL Data Platform (study record HDP00331).

The Johns Hopkins University Prevention Research center - Risks for Transitions, Baltimore city, 2008-2011 study (JHU PRC Risks for Transition in Drug Use among Urban Adults) represents data collected for a 25 years follow-up from the original JHU PRC study. At the start of the data collection, a cohort of 2,311 youth were randomly assigned to two classroom-based universal preventive interventions implemented in 43 classrooms of 19 public schools located in 5 socio-demographically distinct areas in Eastern Baltimore. This collection includes data from 1,434 respondents from the original cohort collected in 2008-2012. The mean age of the respondents was 30-32 years old.

Psychopathology (major depressive episode, phobia and anxiety disorders) was assessed using modules from the Composite International Diagnostic Interview-University of Michigan Version, CIDI- UM (WHO, 1997). An antisocial symptom scale adapted from the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC) was administered which consisted of 30 questions that assessed behaviors experienced since turning 18 years of age. The alcohol, tobacco and drug modules of the interview were modeled after NESARC Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV. Types of information in these modules collected include age of onset, use in past year and prior past year, frequency and recency of use, and DSM-IV abuse and dependence criteria. Socioeconomic status indicators, variables on education, employment, marital status, parenthood, social supports, family history of mental health and drug problems, general health, treatment utilization, and life events are included in this dataset.

This dataset includes 3,140 variables.

This study is part of the Seek, Test, Treat and Retain (STTR) Collaboration Project that involved over twenty studies in the fields of HIV and drug abuse. All studies were independently developed, but were chosen for the collaboration because they focused on one or more steps of the HIV treatment cascade: Seek, Test, Treat and Retain. As part of STTR Collaboration Project, the studies were grouped into Criminal Justice-related studies and Vulnerable Population-related studies. The data collected by these studies included twelve common domains (e.g., Demographic characteristics, Mental Health) in each of which a shared questionnaire or instrument was taken up by the studies and adapted to fit the study.

The specific aim for this study was to conduct a placebo-controlled, RCT of VIVITROL or (extended-release naltrexone) (XR-NTX 380mg) among HIV+ persons in jails and prisons meeting DSM-IV criteria for opioid dependence who are transitioning to the community. HIV treatment outcomes (HIV-1 RNA levels, CD4 count, HAART adherence, retention in care), substance abuse (time to relapse to opioid use, % opioid negative urines, opioid craving), adverse side effects and HIV risk behavior (sexual and drug-related risks) outcomes were compared in 150 recruited prisoners and jail detainees in CT and MA who were randomized 2:1 to either XR-NTX 380mg or XR-NTX-placebo. The primary outcome of interest was the proportion with a HIV-RNA less than 400 copies/mL at 6 months. Secondary outcomes included mean CD4 count, antiretroviral adherence, retention on HAART and in HIV care, HIV risk behaviors, time-to-relapse to opioid use, percent opioid negative urines, retention on XR-NTX 380mg and HIV quality of life. Primary and secondary outcomes were assessed for an additional 6 months after completion of the intervention.

The National Survey on Drug Use and Health (NSDUH) series (formerly titled National Household Survey on Drug Abuse) primarily measures the prevalence and correlates of drug use in the United States. Detailed NSDUH 2008 documentation is available from SAMHSA. The surveys are designed to provide quarterly, as well as annual, estimates. Information is provided on the use of illicit drugs, alcohol, and tobacco among members of United States households aged 12 and older. Questions included age at first use as well as lifetime, annual, and past-month usage for the following drug classes: marijuana, cocaine (and crack), hallucinogens, heroin, inhalants, alcohol, tobacco, and nonmedical use of prescription drugs, including pain relievers, tranquilizers, stimulants, and sedatives. The survey covered substance abuse treatment history and perceived need for treatment, and included questions from the Diagnostic and Statistical Manual (DSM) of Mental Disorders that allow diagnostic criteria to be applied. The survey included questions concerning treatment for both substance abuse and mental health related disorders. Respondents were also asked about personal and family income sources and amounts, health care access and coverage, illegal activities and arrest record, problems resulting from the use of drugs, and needle-sharing. Questions introduced in previous administrations were retained in the 2008 survey, including questions asked only of respondents aged 12 to 17. These "youth experiences" items covered a variety of topics, such as neighborhood environment, illegal activities, drug use by friends, social support, extracurricular activities, exposure to substance abuse prevention and education programs, and perceived adult attitudes toward drug use and activities such as school work. Several measures focused on prevention-related themes in this section. Also retained were questions on mental health and access to care, perceived risk of using drugs, perceived availability of drugs, driving and personal behavior, and cigar smoking. Questions on the tobacco brand used most often were introduced with the 1999 survey. For this 2008 survey, Adult mental health questions were added to measure symptoms of psychological distress in the worst period of distress that a person experienced in the past 30 days and suicidal ideation. A split-sample design also was included to administer separate sets of questions to assess impairment due to mental health problems. Background information includes gender, race, age, ethnicity, marital status, educational level, job status, veteran status, and current household composition.

The NIDA Genetics Consortium was created in 1999 and has several overarching missions: (1) identify human chromosomal regions containing genes and/or specific genes that confer susceptibility to drug addiction; (2) create a repository for data (i.e., clinical information and biospecimens containing DNA; (3) generate a database on molecular genetics of drug use disorders and related phenotypes to provide controlled access to collaborative studies with the broader scientific community; and (4) establish a consortium of scientists who meet regularly and collaborate on projects.

Along with the description of the NIDA Genetics Consortium, the Web site outlines policies for access and distribution of DNA and clinical data from NIDA-funded studies on the genetics of addiction vulnerability.

Established in 1995, the Northwestern Juvenile Project assessed alcohol, drug, or mental (ADM) service needs of juvenile detainees. The study took place between the years of 1995 and 1998, sampling 1,829 male and female juvenile detainees within Cook County, Illinois. This study had two specific aims:

1. To assess the juvenile detainees ADM service needs (including psychiatric disorder, comorbidity and functional impairment); and,
2. To determine the extent that juvenile detainees who need ADM services received them while in the custody of the criminal justice system.

This study has four methodological advantages over prior research:

1. Stratified random sampling;
2. Sufficiently large N (approximately 600 females and 1200 males);
3. Reliable instruments; and
4. Comorbidity data.

Questions for respondents generally pertain to demographics, medical and sexual history, criminal history, aptitude and mental health assessment, familial and social relations, drug abuse, and education.

This study contains data from the first follow-up interview of the Northwestern Juvenile Project (NJP), a longitudinal assessment of alcohol, drug, or mental service treatment needs of juvenile detainees. This initial follow-up occurred approximately three years after the baseline interview and focused on studying the development and persistence of psychiatric disorders, related predictive variables, patterns of drug use, and other risk behaviors.

The project's aims included studying (1) development and persistence of alcohol, drug, and mental disorders and (2) pathways and patterns of risky behaviors. Changes in disorders over time were studied (including onset, remission, and recurrence), comorbidity, associated functional impairments, and the risk and protective factors related to these disorders and impairments. This study addressed patterns and sequences of the development of drug use and related variables, focusing on gender differences, racial/ethnic differences, the antecedents of these risky behaviors (risk and protective factors), and how these behaviors were interrelated.

The original sample included 1829 randomly selected youth, 1172 males and 657 females, then 10 to 18 years old, enrolled in the study as they entered the Cook County Juvenile Temporary Detention Center from 1995 to 1998. Among the sample were 1005 African Americans, 524 Hispanics, 296 non-Hispanic white respondents. Participants were tracked from the time they left detention. Re-interviews were conducted regardless of where respondents were living when their follow-up interview was due: in the community, correctional settings, or by telephone if they lived farther than two hours from Chicago.

This study contains data from the second follow-up interview of the Northwestern Juvenile Project (NJP), a longitudinal assessment of alcohol, drug, or mental service treatment needs of juvenile detainees. This second follow-up occurred approximately 3.5 years after the baseline interview and focused on the development and persistence of psychiatric disorders, related predictive variables, patterns of drug use, and other risky behaviors.

The project's aims included studying (1) development and persistence of alcohol, drug, and mental disorders and (2) pathways and patterns of risky behaviors. Researchers studied changes in disorders over time (including onset, remission, and recurrence), comorbidity, associated functional impairments, and the risk and protective factors related to these disorders and impairments. The NJP addressed the patterns and sequences of the development of drug use and related variables, focusing on gender differences, racial/ethnic differences, the antecedents of these risky behaviors (risk and protective factors), and how these behaviors are interrelated.

The original sample included 1829 randomly selected youth, 1172 males and 657 females, then 10 to 18 years old, enrolled in the study as they entered the Cook County Juvenile Temporary Detention Center from 1995 to 1998. Among the sample were 1,005 African Americans, 524 Hispanics, 296 non-Hispanic white respondents. A random subsample of 997 of the baseline participants were chosen for second follow-up interviews. Researchers tracked participants from the time they left detention and re-interviewed them regardless of where they were living when their follow-up interview was due: in the community, correctional settings, or by telephone if they lived farther than two hours from Chicago.

The study was funded by OJJDP, several institutes at the National Institutes of Health, and other federal agencies and private foundations. The National Institutes of Health funded an additional component on HIV/AIDS risk behaviors.

This study contains data from the third follow-up interview of the Northwestern Juvenile Project (NJP), a longitudinal assessment of alcohol, drug, or mental service treatment needs of juvenile detainees. The third follow-up occurred approximately four years after the baseline interview and focused on studying the development and persistence of psychiatric disorders, related predictive variables, patterns of drug use, and other risk behaviors.

The project's aims included studying (1) development and persistence of alcohol, drug, and mental disorders and (2) pathways and patterns of risky behaviors. Changes in disorders over time were studied (including onset, remission, and recurrence), comorbidity, associated functional impairments, and the risk and protective factors related to these disorders and impairments. This study addressed patterns and sequences of the development of drug use and related variables, focusing on gender differences, racial/ethnic differences, the antecedents of these risky behaviors (risk and protective factors), and how these behaviors were interrelated.

The original sample included 1829 randomly selected youth, 1172 males and 657 females, then 10 to 18 years old, enrolled in the study as they entered the Cook County Juvenile Temporary Detention Center from 1995 to 1998. Among the sample were 1005 African Americans, 524 Hispanics, 296 non-Hispanic white respondents. Participants were tracked from the time they left detention. A random subsample of 997 of the baseline participants were chosen for third follow-up interviews. Re-interviews were conducted regardless of where respondents were living when their follow-up interview was due: in the community, correctional settings, or by telephone if they lived farther than two hours from Chicago.

This study contains data from the fourth follow-up interview of the Northwestern Juvenile Project (NJP), a longitudinal assessment of alcohol, drug, or mental service treatment needs of juvenile detainees. The fourth follow-up occurred approximately 4.5 years after the baseline interview and focused on studying the development and persistence of psychiatric disorders, related predictive variables, patterns of drug use, and other risk behaviors.

The project's aims included studying (1) development and persistence of alcohol, drug, and mental disorders and (2) pathways and patterns of risky behaviors. Changes in disorders over time were studied (including onset, remission, and recurrence), comorbidity, associated functional impairments, and the risk and protective factors related to these disorders and impairments. This study addressed patterns and sequences of the development of drug use and related variables, focusing on gender differences, racial/ethnic differences, the antecedents of these risky behaviors (risk and protective factors), and how these behaviors were interrelated.

The original sample included 1829 randomly selected youth, 1172 males and 657 females, then 10 to 18 years old, enrolled in the study as they entered the Cook County Juvenile Temporary Detention Center from 1995 to 1998. Among the sample were 1005 African Americans, 524 Hispanics, 296 non-Hispanic white respondents. Participants were tracked from the time they left detention. All participants were eligible for fourth follow-up interviews. Re-interviews were conducted regardless of where respondents were living when their follow-up interview was due: in the community, correctional settings, or by telephone if they lived farther than two hours from Chicago.

This study contains data from the fifth follow-up interview of the Northwestern Juvenile Project (NJP), a longitudinal assessment of alcohol, drug, or mental service treatment needs of juvenile detainees. The fifth follow-up occurred approximately 6 years after the baseline interview and focused on studying the development and persistence of psychiatric disorders, related predictive variables, patterns of drug use, and other risk behaviors.

The project's aims included studying (1) development and persistence of alcohol, drug, and mental disorders and (2) pathways and patterns of risky behaviors. Changes in disorders over time were studied (including onset, remission, and recurrence), comorbidity, associated functional impairments, and the risk and protective factors related to these disorders and impairments. This study addressed patterns and sequences of the development of drug use and related variables, focusing on gender differences, racial/ethnic differences, the antecedents of these risky behaviors (risk and protective factors), and how these behaviors were interrelated.

The original sample included 1829 randomly selected youth, 1172 males and 657 females, then 10 to 18 years old, enrolled in the study as they entered the Cook County Juvenile Temporary Detention Center from 1995 to 1998. Among the sample were 1005 African Americans, 524 Hispanics, and 296 non-Hispanic white respondents. Participants were tracked from the time they left detention. All participants were eligible for the fifth follow-up interview. Re-interviews were conducted regardless of where respondents were living when their follow-up interview was due: in the community, correctional settings, or by telephone if they lived farther than two hours from Chicago.