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The Community Vulnerability and Responses to Drug-User-Related HIV/AIDS, 1990-2013 [96 Metropolitan Statistical Areas, United States] (ICPSR 36575)

Released/updated on: 2017-08-08
Geographic coverage: North Carolina, Milwaukee, Indiana, Ocean (New Jersey), Fort Worth, Cincinnati, Austin, Monmouth (New Jersey), Utah, San Jose, Rock Hill, Gastonia, San Diego, Columbus (Ohio), Syracuse, Springfield (Massachusetts), North Little Rock (Arkansas), Arizona, Las Vegas, Arlington, Springfield (Ohio), Boston, San Bernardino, Providence, Seattle, Kentucky, St. Petersburg, Bethlehem, Niagara Falls (New York), Nashville, California, Florida, Delaware, Hunterdon (New Jersey), Boca Raton (Florida), Troy, Knoxville, Mississippi, Fresno, New Haven, Sarasota, Illinois, Newark, Georgia, Little Rock, Virginia, Maryland, Norfolk, Virginia Beach, Suffolk County (New York), United States, Oklahoma, Grand Rapids, Louisville, Waukesha (Wisconsin), Arkansas, Washington, South Carolina, Albany (New York), Wichita, Mesa (Arizona), Carlisle (Pennsylvania), Fall River, Massachusetts, Missouri, Winston-Salem, Holland (Michigan), New Orleans, Scranton, Denver, Salt Lake City, Harrisburg, Dallas, St. Louis, Nevada, Schenectady, Allentown, Raleigh, San Antonio, Muskegon, St. Paul, Clearwater, Hawaii, Rochester (New York), Passaic, Ventura (California), Birmingham, Michigan, Lebanon, Baltimore, New Mexico, Orlando, Louisiana, Toledo, Middlesex (New Jersey), Philadelphia, Riverside, Oklahoma City, Akron, Greensboro, Detroit, Charlotte, High Point, Tucson, Albuquerque, Everett, Oakland, Bakersfield, New York City, Somerset (New Jersey), Petersburg, Memphis, Ogden, Jacksonville, Buffalo, Pittsburgh, Nassau (New York), Orange County (California), Sacramento, El Paso, Greenville, Kansas, Meriden, Pennsylvania, Tulsa, Chapel Hill (North Carolina), West Palm Beach, Iowa, Texas, Lorain, Portland (Oregon), Hazleton, Tampa, Durham, San Marcos (Texas), Indianapolis, Richmond, Oregon, Warwick, Bergen (New Jersey), Newport News, Ann Arbor, Alabama, Cleveland, Dayton, Nebraska, Omaha, Warren, West Virginia, Elyria, Tacoma, Minneapolis, Youngstown, Atlanta, Honolulu, Phoenix, Bradenton, Wilmington (Delaware), Gary, District of Columbia, Rhode Island, Vancouver (Washington), Lodi (California), Chicago, Fort Lauderdale, Wilkes-Barre, Minnesota, Kansas City (Missouri), Bellevue, New York (state), Anderson, New Jersey, Miami, San Francisco, Charleston (South Carolina), Jersey City, Long Beach, Spartanburg (South Carolina), New Hampshire, Easton, Ohio, Los Angeles, Hartford, Stockton, Houston
Time period: 1990-01-01--2013-01-01

The Community Vulnerability and Responses to Drug-User-Related HIV/AIDS, 1990-2013 [96 Metropolitan Statistical Areas, United States] study (CVAR) was a research study of why large United States Metropolitan Statistical Areas (MSAs) vary over time in their vulnerability to HIV/AIDS among drug users and in MSA responses to HIV/AIDS. This collection contains estimates of HIV prevalence among people who injected drugs (PWID) and among sub-populations of PWID. This collection is comprised of ten datasets with differing amounts of variables and provides trend data that describe the following:

  • Epidemiologic outcomes including population prevalence of PWIDs and Non-injecting drug users (NIDUs), and particularly their prevalence among youth; and, among PWIDs, HIV prevalence, late-diagnosis HIV cases, and AIDS incidence and mortality.
  • Implementation of evidence-based drug-related interventions including drug abuse treatment, syringe exchange, HIV counseling and testing.
  • Implementation of non-evidence-based drug-related interventions including incarceration and arrests of drug users.

The collection contains data on the MSA sub-populations including Black, Hispanic, White and "other" race categories. In addition, some statistics are presented in age range categories such as ages 15-29, 30-64 and 15-64.

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EVarQuit: Extinguishing Cigarette Smoking via Extended Pre-Quit Varenicline, Buffalo, New York, 2017-2020 (ICPSR 39157)

Released/updated on: 2025-06-18
Geographic coverage: United States, New York (state), Buffalo
Time period: 2017-10-02--2020-12-09

Learning theory and previous human and animal research support the hypothesis that a longer period of varenicline treatment prior to the target quit date (TQD) will lead to greater reductions in smoking before quitting, and higher long-term cessation rates, compared to standard varenicline treatment.

Building on promising preliminary clinical data, this study tested these hypotheses with a full-scale randomized clinical trial (RCT). 320 treatment-seeking adults reporting smoking at least 5 cigarettes per day (CPD) were randomized to a standard run-in group (3 weeks of placebo, followed by the standard 1 week of pre-TQD varenicline) or an extended run-in group (4 weeks of pre-TQD varenicline). Both groups received brief individual cessation counseling and 11 weeks of post-TQD varenicline.

The primary outcome consisted of cotinine-verified (at end of treatment [EOT]) self-reported continuous abstinence from smoking (in CPD) during the last 4 weeks of treatment. Secondary outcomes included bioverified self-report of continuous abstinence at the 6-month follow-up and percentage of reduction in self-reported smoking rate during the pre-quit period (week 1 vs week 4). Supplemental measures included repeated assessments of craving, withdrawal, medication adherence, and adverse events.

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