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Comparative Effectiveness of Anti-TNF in Combination with Low Dose Methotrexate vs Anti-TNF Monotherapy in Pediatrics Crohn's Disease (COMBINE), United States, 2015-2022 (ICPSR 38680)

Released/updated on: 2024-05-14
Geographic coverage: United States
Time period: 2015-01-01--2022-12-31

The COMBINE study was a longitudinal examination of pediatric Crohn's Disease (CD) patients in the United States with data collected from 2015-2022. This study was a randomized, double blind, placebo controlled pragmatic trial to compare low dose oral methotrexate versus a placebo in children with Crohn's disease initiating anti-TNF (tumor necrosis factor) therapy with Infliximab or Adalimumab. Eligible participants were randomized with a 1:1 allocation and followed for a minimum of 12 months and maximum of 36 months in the context of routine clinical care. The primary outcome was a composite of indicators of treatment failure and/or toxicity. Secondary outcomes included patient reported outcomes of pain interference and fatigue.

Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) that affects approximately 600,000 Americans with estimated direct costs of $3.6 billion annually. Typical symptoms (e.g., abdominal pain, bloody diarrhea) result in substantial morbidity, including hospitalization and surgery, missed work and school, and diminished quality of life. The primary treatment goals for all CD patients are to induce remission by eradicating intestinal inflammation and related symptoms and maintain remission by preventing disease flares and progression. Additional treatment goals for pediatric CD include restoring physical and emotional development.

Curated

National Household Survey on Drug Abuse, 1993 (ICPSR 6852)

Released/updated on: 2013-05-06
Geographic coverage: United States
Time period: 1993-01-01--1993-12-31
This series measures the prevalence and correlates of drug use in the United States. The surveys are designed to provide quarterly, as well as annual, estimates. Information is provided on the use of illicit drugs, alcohol, anabolic steroids, and tobacco among members of United States households aged 12 and older. Data are also provided on treatment for drug use and on illegal activities related to drug use. Questions include age at first use, as well as lifetime, annual, and past-month usage for the following drug classes: marijuana, inhalants, cocaine, hallucinogens, heroin, alcohol, tobacco, and nonmedical use of psychotherapeutics. Respondents were also asked about problems resulting from their use of drugs, alcohol, and tobacco, their perceptions of the risks involved, insurance coverage, and personal and family income sources and amounts. Demographic data include gender, race, ethnicity, educational level, job status, income level, household composition, and population density.
Curated

National Household Survey on Drug Abuse, 1992 (ICPSR 6887)

Released/updated on: 2013-05-06
Geographic coverage: United States
Time period: 1992-01-01--1992-12-31
This series measures the prevalence and correlates of drug use in the United States. The surveys are designed to provide quarterly, as well as annual, estimates. Information is provided on the use of illicit drugs, alcohol, anabolic steroids, and tobacco among members of United States households aged 12 and older. Data are also provided on treatment for drug use and on illegal activities related to drug use. Questions include age at first use, as well as lifetime, annual, and past-month usage for the following drug classes: marijuana, inhalants, cocaine, hallucinogens, heroin, alcohol, tobacco, and nonmedical use of psychotherapeutics. Respondents were also asked about problems resulting from their use of drugs, alcohol, and tobacco, their perceptions of the risks involved, insurance coverage, and personal and family income sources and amounts. Demographic data include gender, race, ethnicity, educational level, job status, income level, household composition, and population density.
Curated

CBS News/Vanity Fair Monthly Poll, October 2009 (ICPSR 30403)

Released/updated on: 2011-05-04
Geographic coverage: United States
Time period: 2009-10-01--2009-10-31
This poll, fielded October 5-7, 2009, is a part of a continuing series of monthly surveys that solicit public opinion on the presidency and on a range of other political and social issues. Respondents were asked whether they approved of the way United States President Barack Obama was handling the presidency and issues such as the economy, foreign policy, health care, and the situations with Afghanistan and Iran. Opinions were solicited about the most important problem facing the country, the condition of the economy, and the way United States Congress was handling its job. Respondent's views about health care were sought and included their opinions about whether they believed the nation's health care system worked well, whether they approved of the way Democrats and Republicans in Congress were handling health care reform, their opinions of the tone of the health care debate, whether they thought health care reform would help or hurt them personally, and the likelihood Congress would pass and Obama would sign the health care reform bill into law by the end of 2009. Respondents were also asked several other questions about health care, including whether they favored the government offering everyone a government administered health insurance plan, whether they thought Democrats and Republicans were serious about reforming the health care system, and who the Democrats and Republicans were trying to help more in their health care reform proposals. Information was collected on the financial situation of the respondent's household, whether they had health insurance coverage, and the source of their insurance coverage. Additional topics addressed abortion, the war in Afghanistan, Iran's threat to the United States, opinions of cellular phones usage while driving, the swine flu, job security, assisted suicide, steroid use in professional sports, marijuana and prostitution legalization, the social networking Internet site Facebook, and the most useful technological advances of the past. Demographic variables include sex, age, race, education level, marital status, household income, employment status, perceived social class, political party affiliation, political philosophy, voter registration status and participation history, religious preference, the presence of adults between the ages of 18 and 29 in the household, whether respondents had children under the age of 18 years, and whether they considered themselves to be a born-again Christian.
Curated

Criminal Justice Drug Abuse Treatment Studies (CJ-DATS): National Criminal Justice Treatment Program (NCJTP) Survey in the United States, 2002-2008 (ICPSR 27382)

Released/updated on: 2010-08-09
Geographic coverage: District of Columbia, United States
Time period: 2002-01-01--2008-12-31
The National Criminal Justice Treatment Practices (NCJTP) Survey provides a comprehensive inquiry into the nature of programs and services provided to adult and juvenile offenders involved in the justice system in the United States. Participants included key criminal justice administrators, operations managers, and staff. This survey was conducted in all 50 states and the District of Columbia. The survey involved a myriad of state, regional, and local organizations employing a mix of their own staff and contracted personnel, and services that might involve multiple levels of government. It was a self-administrated, paper-and-pencil questionnaire. The methodology included a multilevel approach that captured the perspective of executives, front-line administrators, and line staff about current practices in a range of institutional and community correctional settings for adults and juveniles. The goals for this survey were: to describe current drug treatment practices, policies, and delivery systems for offenders on probation or parole supervision, and in jails, prisons, and youth institutions; to examine agency structures, resources, and other organizational factors that may affect service delivery, including mission, leadership, climate, culture, and beliefs about rehabilitation versus punishment; and to assess coordination and integration across criminal justice agencies and between corrections and treatment systems. Items in the survey included: respondent characteristics, organizational characteristics, correctional programs characteristics (e.g., size, nature, etc.), substance abuse treatment programs characteristics, social networks/agencies collaboration, integration of services with other agencies, attitudes toward punishment and rehabilitation (personal values), organizational needs assessment, organizational culture and climate for treatment, cynicism toward change, organizational commitment to treatment, and perspectives on intradepartmental coordination.
Curated

CBS News/New York Times Monthly Poll, February 2009 (ICPSR 26944)

Released/updated on: 2010-05-05
Geographic coverage: United States
Time period: 2009-02-01--2009-02-28
This poll, fielded February 18-22, 2009, is part of a continuing series of monthly surveys that solicit public opinion on the presidency and on a range of other political and social issues. Respondents were asked whether they approved of the way Barack Obama was handling the presidency and issues such as the economy, the war in Iraq, and foreign policy. Respondents gave their opinions of First Lady Michelle Obama, the United States Congress, the Republican and Democratic parties, and how they will work together. Views were sought on the condition of the national economy, the government bailout of the automotive and financial industries, and whether the federal government should provide financial help to homeowners having trouble paying their mortgages. Additional topics addressed the stimulus package, the national debt, baseball players and steroid use by the players, household finances, job security, the wars in Iraq and Afghanistan, whether Iran was a threat to the United States, whether the Bush Administration should be investigated for the treatment of detainees, the use of wiretaps, the likelihood that respondents would watch President Obama's address to Congress on February 24th, 2009. Demographic variables include sex, age, race, marital status, education level, household income, home ownership, employment status, perceived social class, political party affiliation, political philosophy, voter registration status and participation history, religious preference, and whether respondents considered themselves to be a born-again Christian.
Curated

CBS News Call-Back Poll, March 2008 (ICPSR 26145)

Released/updated on: 2009-10-29
Geographic coverage: United States
Time period: 2008-03-01--2008-03-31
This call-back poll, fielded March 20, 2008, is a part of a continuing series of monthly surveys that solicits public opinion on the presidency and on a range of other political and social issues. This poll surveyed 542 registered voters first interviewed March 15-18, 2008, in the CBS NEWS MONTHLY POLL #1, MARCH 2008 (ICPSR 26144), which queried respondents on George W. Bush's presidency, the condition of the national economy, the 2008 presidential race, the news media's treatment of the candidates, the effect of race and gender on the choice of a presidential candidate, and sexism and racism in America. In the call-back poll conducted on March 20, 2008, registered voters from the original survey were asked for their reactions to Barack Obama's March 18, 2008, speech on race relations in the United States, how much they had heard or read about Obama's relationship with Reverend Jeremiah Wright, whether they agreed with Obama's stance on race relations in the United States, their opinions of him, whether they were more likely to vote for him, and whether he would be the kind of president who could unite the country. Demographic variables include sex, age, race, education level, marital status, whether respondents had children under 18 years of age, household income, political party affiliation, political philosophy, voter registration status and participation history, religious preference, frequency of religious attendance, and whether respondents considered themselves to be a born-again Christian.
Curated

CBS News Monthly Poll #1, March 2008 (ICPSR 26144)

Released/updated on: 2009-10-08
Geographic coverage: United States
Time period: 2008-03-01--2008-03-31
This poll, fielded March 15-18, 2008, is a part of a continuing series of monthly surveys that solicit public opinion on the presidency and on a range of other political and social issues. This poll included an oversample of African Americans, for a total of 122 African American respondents. Respondents were asked whether they approved of the way George W. Bush was handling the presidency, the economy, and the situation in Iraq, to rate the condition of the national economy, to indicate the most important issue for candidates to discuss in the 2008 presidential election, and the preferred qualities and characteristics in a presidential candidate. Registered voters were asked how much attention they were paying to the 2008 presidential campaign, whether they planned to or had already voted in a Democratic or Republican primary or caucus in their state, their opinions of candidates John McCain, Barack Obama, and Hillary Clinton, and which candidate they would vote for if the general election were held that day. Views were sought on the news media's treatment of the candidates, whether it was appropriate for candidates to show their emotions in public, whether respondents and most people they knew would vote for a presidential candidate who was African American or a woman, whether people they knew had made sexist or racist remarks in the past few months, and whether racism or sexism was a more serious problem in the country. Registered Democratic primary voters were asked about the Democratic presidential nomination process and how superdelegates should decide their vote at the convention. Additional questions queried all respondents on Obama's minister Reverend Jeremiah Wright, major league baseball, steriod use in professional sports, the war in Iraq and its effect on the threat of terrorism against the United States, and whether Saddam Hussein was personally involved in the terrorist attacks of September 11, 2001. Demographic variables include sex, age, race, education level, marital status, whether respondents had children under 18 years of age, household income, political party affiliation, political philosophy, voter registration status and participation history, religious preference, frequency of religious attendance, and whether respondents considered themselves to be a born-again Christian.
Curated

CBS News/New York Times Monthly Poll, April 2007 (ICPSR 23443)

Released/updated on: 2008-12-16
Geographic coverage: United States
Time period: 2007-04-01--2007-04-30
This poll, fielded April 20-24, 2007, is a part of a continuing series of monthly surveys that solicits public opinion on the presidency and on a range of other political and social issues. Respondents were asked to say whether they approved of the way George W. Bush was handling his job as president and other issues such as the war in Iraq, to rate the condition of the environment in the world and their own community, and whether the Republican party or the Democratic party was more likely to protect the environment, make the United States less dependent on foreign oil, and ensure the United States has enough sources of energy. Respondents were asked several questions about protecting the environment, including which environmental problem was the most important, whether they would vote for a candidate based on their views of the environment, the responsibility of federal and state governments to set environmental protections, drilling for oil and gas in the Arctic National Wildlife refuge in Alaska, and whether it was more important to stimulate the economy or protect the environment. Respondents were asked whether the Iraq war has affected the price of gasoline, whether they would favor an increased tax on gasoline if it would reduce the United States' dependence on foreign oil or if the money was used for research into renewable sources such as solar and wind energy, and whether using ethanol as a substitute for foreign oil is a good idea. Respondents were asked whether they would approve of building more plants powered by coal to generate electricity, whether using coal, natural gas, nuclear power, and/or renewable sources to generate electricity was a good idea, and whether global warming needs to be a priority for government leaders. They were also asked about the causes of global warming and ways to reduce global warming. Other topics included the firings of United States attorneys by the Justice Department and Attorney General Alberto Gonzales, United States troop levels and withdrawal from Iraq, whether respondents recycle and purchase recycled and/or energy-efficient products, car pool to work or use mass transit, and whether they would seriously consider buying or leasing a hybrid vehicle. Additional topics included the laws covering the sale of handguns, gun control, and the Virginia Tech shooting incident, respondents' own financial situation, horse racing and the Triple Crown races, professional basketball, and athlete's use of steroids. Demographic information includes sex, age, race, education level, household income, marital status, military service, religious preference, frequency of religious attendance, type of residential area (e.g., urban or rural), political party affiliation, political philosophy, voter registration status and participation history, the presence of children under 18 and household members between the ages of 18 and 24, and whether respondents had any children planning to attend a four-year college.
Curated

CBS News/New York Times Monthly Poll, May 2007 (ICPSR 23444)

Released/updated on: 2008-11-14
Geographic coverage: United States
Time period: 2007-05-01--2007-05-31
This poll, fielded May 18-23, 2007, is a part of a continuing series of monthly surveys that solicit public opinion on the presidency and on a range of other political and social issues. An oversample of African Americans was conducted for this poll. Respondents were asked whether they approved of the way George W. Bush was handling the presidency and issues such as immigration and foreign policy. Views were sought on Vice President Dick Cheney, the United States Congress, the most important problem facing the country, and the condition of the national economy. Those who were registered to vote were asked how closely they were following the 2008 presidential campaign, whether they were more likely to vote in a Democratic or Republican primary, for whom they would vote, their opinion of the nominees from each party, and which party they trusted to handle foreign policy and immigration issues. A series of questions addressed immigration policy in the United States, the effect of legal and illegal immigration on the economy, society, crime, and terrorism, whether immigration should be kept at current levels, and respondents' opinions of proposed solutions for dealing with illegal immigration. Additional topics addressed the war in Iraq, abortion, baseball star Barry Bonds, and steroid use in professional sports. Information was also collected on whether respondents were born in the United States, whether they had been raised in a non-English speaking household, and whether they had regular contact with anyone who was a legal or illegal immigrant to the United States. Demographic information includes sex, age, race, education level, marital status, United States citizenship status, household income, religious preference, frequency of religious attendance, military service, political party affiliation, political philosophy, voter registration status and participation history, type of residential area (e.g., urban or rural), the presence of children under 18 and household members between the ages of 18 and 24, and whether respondents had children attending a four-year college.
Curated

ABC News/ESPN Barry Bonds Poll, July 2006 (ICPSR 4662)

Released/updated on: 2008-04-16
Geographic coverage: United States
Time period: 2006-07-01--2006-07-31
This special topic poll was conducted by ABC News and ESPN and sought respondents' views on Barry Bonds and the use of steroids in Major League Baseball. Respondents were asked to give their opinions on whether the use of steroids and performance-enhancing drugs was a problem in baseball. Respondents were further asked whether they thought Barry Bonds had utilized steroids or performance-enhancing drugs and whether that would have an impact on how they felt about him potentially breaking baseball's homerun record. Questions were also solicited regarding the possibility of Barry Bonds being elected to the Hall of Fame and whether the use of steroids or a conviction of tax evasion should prevent him from being selected. Demographic variables include race, gender, age, level of education, employment status, income, political party affiliation, political philosophy, and religious affiliation.
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