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Comparative Effectiveness PTSD Trial of Sequenced Pharmacotherapy and Psychotherapy in Primary Care, 11 U.S. States, 2021-2024 (ICPSR 39425)

Released/updated on: 2025-12-15
Geographic coverage: Oregon, Montana, United States, Texas, Massachusetts, Colorado, Ohio, California, Arkansas, Washington, South Carolina, Michigan
Time period: 2021-04-01--2024-06-30

Based on the state of the scientific evidence, the Sequenced Treatment Effectiveness for Posttraumatic Stress (STEPS) Trial was designed to address three specific aims. The first aim was to quantitatively compare engagement, self-reported PTSD symptom severity (primary outcome), quality of life, and recovery outcomes of primary care patients randomized to initially receive brief psychotherapy (Written Exposure Therapy - WET) or their choice of the three selective serotonin reuptake inhibitors (SSRIs). The second aim was, among patients not responding to initial treatment, to quantitatively compare outcomes of primary care patients randomized to: 1) augment the SSRI with WET, 2) switch from the SSRI to another class of antidepressants (serotonin-norepinephrine reuptake inhibitors - SNRI), or 3) switch from WET to the choice of the three SSRIs. The third specific aim was to quantitatively examine treatment heterogeneity among subgroups of primary care patients receiving pharmacotherapy and psychotherapy, including veterans, women, and those using cannabis.

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Project on Human Development in Chicago Neighborhoods (PHDCN): Depression, Wave 3, 2000-2002 (ICPSR 13691)

Released/updated on: 2007-02-06
Geographic coverage: United States, Chicago, Illinois
Time period: 2000-01-01--2002-12-31
The Project on Human Development in Chicago Neighborhoods (PHDCN) was a large-scale, interdisciplinary study of how families, schools, and neighborhoods affect child and adolescent development. One component of the PHDCN was the Longitudinal Cohort Study, which was a series of coordinated longitudinal studies that followed over 6,000 randomly selected children, adolescents, and young adults, and their primary caregivers over time to examine the changing circumstances of their lives, as well as the personal characteristics, that might lead them toward or away from a variety of antisocial behaviors. Numerous measures were administered to respondents to gauge various aspects of human development, including individual differences, as well as family, peer, and school influences. One such measure was the Depression survey. It was administered to subjects' primary caregivers for Cohorts 0, 3, 6, 9, 12, and 15 and to subjects for Cohort 18. The instrument was adapted from the short form of the Composite International Diagnostic Interview (UM-CIDI) and obtained information about depressive symptoms experienced by the respondent during the past year. It is similar to PROJECT ON HUMAN DEVELOPMENT IN CHICAGO NEIGHBORHOODS (PHDCN): DEPRESSION, WAVE 2, 1997-2000 (ICPSR 13614).
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Project on Human Development in Chicago Neighborhoods (PHDCN): Dysthymia, Wave 2, 1997-2000 (ICPSR 13616)

Released/updated on: 2005-11-22
Geographic coverage: United States, Chicago, Illinois
Time period: 1997-01-01--2000-12-31
The Project on Human Development in Chicago Neighborhoods (PHDCN) was a large-scale, interdisciplinary study of how families, schools, and neighborhoods affect child and adolescent development. One component of the PHDCN was the Longitudinal Cohort Study, which was a series of coordinated longitudinal studies that followed over 6,000 randomly selected children, adolescents, and young adults, and their primary caregivers over time to examine the changing circumstances of their lives, as well as the personal characteristics, that might lead them toward or away from a variety of antisocial behaviors. Numerous measures were administered to respondents to gauge various aspects of human development, including individual differences, as well as family, peer, and school influences. The Dysthymia survey was administered to subjects' primary caregivers for Cohorts 0 to 15. The instrument was adapted from the short form of the Composite International Diagnostic Interview (UM-CIDI) and obtained information about depressive symptoms experienced by the primary caregiver during the past two years.
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Project on Human Development in Chicago Neighborhoods (PHDCN): Depression, Wave 2, 1997-2000 (ICPSR 13614)

Released/updated on: 2005-11-14
Geographic coverage: United States, Chicago, Illinois
Time period: 1997-01-01--2000-12-31
The Project on Human Development in Chicago Neighborhoods (PHDCN) was a large-scale, interdisciplinary study of how families, schools, and neighborhoods affect child and adolescent development. One component of the PHDCN was the Longitudinal Cohort Study, which was a series of coordinated longitudinal studies that followed over 6,000 randomly selected children, adolescents, and young adults, and their primary caregivers over time to examine the changing circumstances of their lives, as well as the personal characteristics, that might lead them toward or away from a variety of antisocial behaviors. Numerous measures were administered to respondents to gauge various aspects of human development, including individual differences, as well as family, peer, and school influences. The Depression survey was administered to subjects' primary caregivers for Cohorts 0 to 15. The instrument was adapted from the short form of the Composite International Diagnostic Interview (UM-CIDI) and obtained information about depressive symptoms experienced by the primary caregiver during the past year.
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