The Aspirin Myocardial Infarction Study was conducted to determine whether the daily administration of at least one gram of aspirin to persons who had at least one documented myocardial infarction would result in a significant reduction in total mortality over a three year period. Secondary objectives were to evaluate the effects of aspirin in this group on the incidence of coronary heart disease mortality, coronary incidence, fatal or nonfatal strokes, and intermittent cerebral ischemic attacks. Other objectives were to evaluate side or adverse effects of long-term aspirin therapy, to study the natural history of coronary heart disease by following patients in a placebo group, and to advance the methodology of long-term cooperative clinical trials. Initial Visit Form variables include age, sex, race, birthdate, lifestyle, work status, and marital status, as well as thorough physical examinations to determine the patient's general condition. Included in the first and followup exams are variables on heart problems, other medical problems, causes of death, medications, smoking, alcohol consumption, and extensive laboratory tests.
Patients were recruited by thirty Clinical Centers throughout the United States, including Hawaii, the District of Columbia, and Puerto Rico. Randomized, double-blind study.
Population of adults aged 30-69, with documented evidence of previous myocardial infarction(s).
Original Release Date
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