Center for Education and Drug Abuse Research (CEDAR): Etiological and Prospective Family Study in Southwestern Pennsylvania, Baseline and Follow-Up Data, 1990-2014 (ICPSR 33444)

Version Date: Jun 30, 2021

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Principal Investigator(s):
Ralph E. Tarter, University of Pittsburgh. School of Pharmacy

https://doi.org/10.3886/ICPSR33444.v2

Version V2 ()

  • V2 [2021-06-30]
  • V1 [2012-08-10] unpublished
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Summary

The Center for Education and Drug Abuse Research (CEDAR) conducted research on 775 families enrolled in the Center's prospective investigations into the etiology of substance use disorder (SUD). The pro-bands are men with lifetime presence/absence of SUD consequent to use of an illicit drug who have a 10-12 year old biological son or daughter. The biological children of SUD men are assigned to the high average risk (HAR) group whereas offspring of men without SUD, having neither axis 1 disorder ("normal") nor SUD psychiatric disorder, are assigned to the low average risk (LAR) group. A second control group (Psych control) was also collected, in whom the fathers had a lifetime DSM-III-R diagnosis of any psychiatric disorder not related to substance use. The sample sizes are as follows: HAR = 344, LAR = 350, and Psych = 81. The children had follow-up evaluations conducted at ages 12-14, 16, 19, and annually thereafter until age 30. CEDAR has already shown that they can predict in 10-12 year old youth cannabis use disorder by age 22 with approximately 70 percent accuracy, thereby substantiating the paradigm, subject recruitment strategy, and measurement protocols. Multidisciplinary research was conducted on family members (father, mother, children) with the objective of elucidating the genetic, bio-behavioral, and environmental factors on development of SUD consequent to use of illegal drugs. Research protocols are organized into three thematically connected research modules (Neurogenetics, Developmental Psychopathology, and Translation) linking etiology and prevention. The research components thus align with the NIH Roadmap model such that basic science informs clinical research leading to prevention guided by an understanding of etiology. In addition to module-level research, faculty also participate in three organizational aims: (1) Devise a practical scale to quantify the transmissible liability to SUD; (2) Empirically test a bio-psychological theory of SUD etiology focusing on off-time maturation leading to psychological dysregulation predisposing to SUD; and, (3) Delineate SUD liability variants within an ontogenetic framework.

Citation

Tarter, Ralph E. Center for Education and Drug Abuse Research (CEDAR): Etiological and Prospective Family Study in Southwestern Pennsylvania, Baseline and Follow-Up Data, 1990-2014. Inter-university Consortium for Political and Social Research [distributor], 2021-06-30. https://doi.org/10.3886/ICPSR33444.v2

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Funding

United States Department of Health and Human Services. National Institutes of Health. National Institute on Drug Abuse (P50 DA 005605)

Subject Terms

Geographic Coverage

Smallest Geographic Unit

Census tract

Restrictions

Access to these data is restricted. Users interested in obtaining these data must complete a Restricted Data Use Agreement, specify the reason for the request, and obtain IRB approval or notice of exemption for their research.

Distributor(s)

Inter-university Consortium for Political and Social Research
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Time Period(s)

1990 -- 2014

Date of Collection

1990-01-05 -- 2008-09-23 (Visit 1 (ages 10-12); index cases only, groups 1, 2, and 3), 1992-02-24 -- 2012-01-20 (Visit 2 (ages 12-14); index cases only, groups 1, 2, and 3), 1994-05-18 -- 2014-10-10 (Visit 3 (age 16); index cases only, groups 1, 2, and 3), 1996-08-07 -- 2014-05-14 (Visit 4 (age 19); index cases only, groups 1, 2, and 3), 2000-03-21 -- 2014-09-25 (Visit 5: (age 22); index cases only, groups 1, 2, and 3), 2002-08-13 -- 2014-12-17 (Visit 6: (age 25); index cases only, groups 1, 2, and 3), 2005-03-03 -- 2014-12-10 (Visit 7: (age 27); index cases only, groups 1, 2, and 3), 2007-04-23 -- 2014-12-17 (Visit 8: Age 30; index cases only, groups 1, 2, and 3), 1996-05-03 -- 2009-01-14 (Sibling (completing index protocol); Baseline), 1998-05-04 -- 2010-12-03 (Sibling (completing index protocol); first follow up), 2000-04-05 -- 2012-12-12 (Sibling (completing index protocol); second follow up), 2002-09-20 -- 2014-11-24 (Sibling (completing index protocol); third follow up), 2006-03-08 -- 2014-12-05 (Sibling (completing index protocol); fourth follow up), 2008-04-29 -- 2014-10-28 (Sibling (completing index protocol); fifth follow up), 2011-06-16 -- 2014-12-19 (Sibling (completing index protocol); sixth follow up), 2013-08-11 -- 2014-12-18 (Sibling (completing index protocol); seventh follow up)

Data Collection Notes

  1. For more information regarding the CEDAR study measures, users are encouraged to see the Center for Education and Drug Abuse Research (CEDAR) Web site.

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Study Design

Three groups of male and female children are studied for a 20-year period: (1) Offspring of substance abusing fathers, (2) Offspring of normal fathers, and (3) Offspring of psychiatrically disordered fathers. The three groups are longitudinally tracked from age 10-12 until they reach age 30 using the following assessment schedule: age 10-12, age 12-14, age 16, age 19, age 22, age 25, age 27, age 30. Brief annual updates were also collected between ages 19 and 30.

Sample

The sample uses a high risk paradigm, in which the families were selected based on a DSM-III-R diagnosis of substance use disorder in the biological father of the index child (High Average Risk, or HAR group) versus NO DSM-III-R psychiatric disorder (Low Average Risk, or LAR group). A second control group (Psych control) was also collected, in whom the fathers had a lifetime DSM-III-R diagnosis of any psychiatric disorder not related to substance use. The sample sizes are as follows: HAR = 344, LAR = 350, and Psych = 81. Citation: Tarter, R.E., Vanyukov, M.M. (2001). Introduction: Theoretical and operational framework for research into the etiology of substance use disorders. Journal of Child and Adolescent Substance Abuse 10 (4):1-12.

Time Method

Longitudinal: Panel: Continuous

Universe

Fathers, mothers, and biological children ages 10-12 in 1990 in Southeastern Pennsylvania whose father had a lifetime presence/absence of substance abuse disorder consequent to use of an illicit drug.

Unit(s) of Observation

Individual; Household

Data Type(s)

Mode of Data Collection

Presence of Common Scales

The study utilized the following measurement tools:

  • Child Behavior Checklist (CBCL).
  • Dimensions of Temperament - Revised (DOTs-R).
  • Family Assessment Measure (FAM).
  • Health Problems Checklist (HPQ).
  • Multidimensional Personality Questionnaire (MPQ).
  • Youth Self Report (YSR) Achenbach, T.M. (1991). Manual for the Youth Self-Report and 1991 Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
  • Young Adult Self Report (YASR) Achenbach, T.M. (1997) Manual for the Young Adult Self-Report and Young Adult Behavior Checklist. Burlington, VT: Department of Psychiatry, University of Vermont.
  • Adult Self Report (ASR) Achenbach, T.M., and Rescorla, L.A. (2003). Manual for the ASEBA Adult Forms and Profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth and Families.
  • Interpersonal Support Evaluation List (ISEL) Cohen, S. and Hoberman, H.M. (1983). Positive events and social supports as buffers of life change stress. Journal of Applied Social Psychology, 13, 99-125.
  • Social Readjustment Rating Scale Holmes, T.H., and Rahe, R.H. (1967). The social readjustment rating scale. Journal of Psychosomatic Research, 11, 213-218.
  • Life Events Questionnaire Coddington, R.D. (1972). The significance of life events as etiologic factors in the diseases of children. II. Journal of Psychosomatic Research, 16, 205-213.

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    Original Release Date

    2012-08-10

    Version History

    2021-06-30 Updated and added datasets; updated documentation.

    2018-02-15 The citation of this study may have changed due to the new version control system that has been implemented. The previous citation was:
    • Tarter, Ralph E. Center for Education and Drug Abuse Research (CEDAR): Etiological and Prospective Family Study in Southwestern Pennsylvania, Baseline and Follow-Up Data, 1990-2014. ICPSR33444-v2. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2021-06-30. http://doi.org/10.3886/ICPSR33444.v2

    2012-08-10 ICPSR data undergo a confidentiality review and are altered when necessary to limit the risk of disclosure. ICPSR also routinely creates ready-to-go data files along with setups in the major statistical software formats as well as standard codebooks to accompany the data. In addition to these procedures, ICPSR performed the following processing steps for this data collection:

    • Created variable labels and/or value labels.
    • Standardized missing values.
    • Checked for undocumented or out-of-range codes.
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    Notes

    • The public-use data files in this collection are available for access by the general public. Access does not require affiliation with an ICPSR member institution.

    • One or more files in this data collection have special restrictions. Restricted data files are not available for direct download from the website; click on the Restricted Data button to learn more.

    NAHDAP logo

    This study is maintained and distributed by the National Addiction & HIV Data Archive Program (NAHDAP). NAHDAP is supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH).