Daily Experience in Adolescence and Biomarkers of Early Risk for Adult Health (ICPSR 35952)

Principal Investigator(s): View help for Principal Investigator(s)
Andrew J. Fuligni, University of California-Los Angeles

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This project conducts a 3-wave longitudinal study of adolescents and their caregivers from Mexican, Chinese, and European backgrounds in order to assess the impact of daily experience on biological indicators of early risk for adult health. It includes intensive behavioral assessments and detailed biological markers of health risk from both adolescents and their parents. Approximately 540 pairs of adolescents and their primary caregivers (180 from each ethnic group) are assessed when the adolescents are approximately 15-16, 17-18, and 19-20 years old. Each year, both adolescents and caregivers participate in interviews that include measures of global social factors and potential protective factors. Participants report daily experiences using a nightly diary checklist for 9 consecutive days. Salivary cortisol is obtained at 4 time points each day for 4 of these days in order to analyze HPA activity, and participants wear wrist actigraphs for the same 4 days to measure objective sleep behaviors. Blood pressure, BMI, and waist/hip ratio are assessed, and dried blood spots are obtained for the assessment of c-reactive-protein (CRP), cholesterol, and high density lipoproteins (HDL). Finally, peripheral blood samples are provided by a subsample of 120 families for the assessment of plasma interleukin-6 (IL-6), a pro-inflammatory cytokine, and for gene expression analyses of molecular signaling pathways driving inflammatory biology.

United States Department of Health and Human Services. National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development (5R01HD062547)

NICHD funded the PRIMARY DATA COLLECTION of this project.

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observational data