Hawaii Aging with HIV Cardiovascular Study, 2009-2014 (ICPSR 36389)

Principal Investigator(s): Shikuma, Cecilia, University of Hawaii at Manoa. John A. Burns School of Medicine; Chow, Dominic, University of Hawaii at Manoa. John A. Burns School of Medicine


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Hawaii Aging with HIV Cardiovascular Study (HAHCS) enrolled HIV-infected volunteer adults age 40 and over, recruited from the state of Hawaii. A natural history longitudinal study, HAHCS followed a cohort of 150 HIV positive subjects for five years. The study is based on observations that, while HIV-infected individuals now live longer because of the availability of highly active antiretroviral therapy, these individuals may be at increased risk of cardiovascular (CV) morbidity and mortality. Rates of well-accepted traditional CV risk factors such as diabetes/hyperglycemia, body morphology changes and smoking are high in the HIV population. Furthermore, there is growing concern that HIV per se may also contribute to CV risk.

HAHCS evaluated the cross-sectional and longitudinal impact of oxidative stress and inflammation on the development of subclinical atherosclerosis. Researchers assessed subclinical atherosclerosis functionally by brachial artery flow mediated vasodilatation (FMD) and structurally by intima-media thickness (IMT) as well as coronary artery calcium score obtained by dual source CT. Data include behavioral health indicators, medical history information, and medical test results. Demographic data include age, sex, and race.

Access Notes

  • The public-use data files in this collection are available for access by the general public. Access does not require affiliation with an ICPSR member institution.


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Study Description


Shikuma, Cecilia, and Dominic Chow. Hawaii Aging with HIV Cardiovascular Study, 2009-2014. ICPSR36389-v1. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2016-03-10. https://doi.org/10.3886/ICPSR36389.v1

Persistent URL: https://doi.org/10.3886/ICPSR36389.v1

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This study was funded by:

  • United States Department of Health and Human Services. National Institutes of Health. National Heart Lung and Blood Institute (5R01HL095135)

Scope of Study

Subject Terms:    aging population, cardiovascular disease, diabetes, health, health problems, HIV, medicine

Smallest Geographic Unit:    None

Geographic Coverage:    Hawaii, United States

Time Period:   

  • 2009-01--2014-09

Date of Collection:   

  • 2009--2014

Universe:    HIV infected individuals age 40 and over living in Hawaii, receiving stable antiretroviral therapy

Data Type(s):    clinical data

Data Collection Notes:

This collection has not been processed by ICPSR. All of the files are available as deposited by the data producer in one zipped package.


Time Method:    Longitudinal: Panel

Weight:    None

Presence of Common Scales:    CAC, CIMT, FMD


Original ICPSR Release:   2016-03-10


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